Mycobacterium bovis BCG mycobacteria--new application.
نویسندگان
چکیده
The polarized response of T helper-2 (Th2) lymphocytes to an allergen is considered to be the main cause of the pathogenesis of asthma. In this study, we asked a question whether M. bovis BCG mycobacteria which are known for the preferential stimulation of T helper-1 (Th1) immunity, diminish the effector functions of Th2 cells from allergic patients upon stimulation with a common house dust mite Der p-1 allergen. Our results allow a positive answer to this question. We demonstrate that BCG modulates the dendritic cell-dependent allergen presentation process and switches naive T lymphocytes towards an anti-allergic Th1 profile.
منابع مشابه
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عنوان ژورنال:
- Polish journal of microbiology
دوره 55 1 شماره
صفحات -
تاریخ انتشار 2006